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"But we have a long way to go to get to even more effective treatments and eventually a cure."Īnd Saget said that when he meets people with scleroderma, "my word to them is don't give up hope, because we are making incredible progress." "There are new drugs specifically for scleroderma that are helping people," he told NIH Medline Plus.
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The Full House star said in a May 2021 Instagram post that it was "one of my life's missions to help find a cure for this disease." Bob was a deeply caring father, husband, and colleague, who was unreservedly committed to the mission of the SRF." "Bob was a champion for scleroderma patients everywhere dating back to 1991 when he first became involved with the Scleroderma Research Foundation (SRF), even before his sister Gay lost her battle with the disease in 1994. "It is with a very heavy heart that we mourn the loss of our friend and Board member, Bob Saget," they said. The organization shared a tribute to Saget on Monday. John Shearer/WireImage Bob Saget and John Stamos at the 2006 Cool Comedy, Hot Cuisine fundraiser for the Scleroderma Research Foundation They raised $25 million through the years for research and treatment. He was also on the board of directors for the Scleroderma Research Foundation for more than a decade and hosted their events for 25 years, including the annual Cool Comedy, Hot Cuisine fundraiser, where his comedian friends would do standup and attendees would dine on meals from top chefs.
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Saget directed the 1996 TV movie For Hope, about a young woman with scleroderma based on Gay's experience, which helped raise awareness of the disease. Watching Gay's struggle with the disease pushed Saget to become a dedicated advocate for more research into a cure. My family is still having post-traumatic stress disorder. "It is incredibly painful to have a loved one experience a condition like this. "She needed so much help," he told NIH Medline Plus. Saget's sister was diagnosed at age 44, and died two years later, in 1994. RELATED: Bob Saget, Star of Full House and America's Funniest Home Videos, Dies at 65
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There is no direct cure for scleroderma, and instead different treatments that can target the various symptoms of the disease, such as steroid creams for the skin inflammation, blood pressure medications for any lung or kidney problems, immune suppressants and over-the-counter pain relievers. And if scleroderma reaches the digestive system, it can cause heartburn, difficulty swallowing, bloating and diarrhea.
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Scarring of heart tissue could lead to congestive heart failure. Scleroderma in the kidneys can lead to elevated blood pressure and rapid kidney failure. The lungs can develop scar tissue which can make it harder to breathe. But in severe forms, called systemic scleroderma, the disease spreads through other systems in the body and "can damage your blood vessels and internal organs, such as the heart, lungs and kidneys," according to NIH.Īnd if scleroderma spreads through the body, it affects each organ in different ways. In mild cases, scleroderma just affects the skin. The disease causes the skin to form hard, tight patches that can grow or shrink, and sometimes suddenly disappear.
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Scleroderma is a rare, autoimmune connective tissue and rheumatic disease that primarily causes inflammation in the skin, and can lead to inflammation in other parts of the body, according to the National Institutes of Health.